منابع مشابه
Thymus-derived (t) Cell Immunoglobulins
Quantitation of surface and total cell Ig obtained after lysis by detergent, urea-acid treatment, and freeze-thawing were determined on spleen cells, thymus cells, and spleen cells specifically depleted of B cells. A two- to four-fold increase in measurable Ig was found after cell lysis. All cell populations showed a similar increase in measurable Ig indicating that no discordantly large amount...
متن کاملSurface Immunoglobulins on Thymus and Thymus-derived Lymphoid Cells
Lymphoid cells from thymus, thoracic duct lymph (TDL), and thoracic duct lymph in irradiated animals reconstituted with allogeneic thymus cells (TTDL) were labeled with radioiodinated anti-immunoglobulins using radioautographic techniques. Thymus and TTDL were labeled (14.4 and 37.0%, respectively) with anti-light chain protein after prolonged exposures (30-60 days). No labeling was observed on...
متن کاملGenetic Control of Thymus-derived Cell Function
Concanavalin A- or phytohemagglutinin-stimulated DNA synthetic responses of 1 million normal mouse spleen cells in vitro were significantly different among various inbred strains. BALB/cJ (H-2(d)) responded better than C57BL/6J (H-2(b)) spleen cells, and the responses of C3H/HeJ or AKR/J (both H-2(k)) cells were intermediate. These responses, measured as the increment in thymidine-(3)H incorpor...
متن کاملRole of Cytokines in Thymus- Versus Peripherally Derived-Regulatory T Cell Differentiation and Function
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are essential players in the control of immune responses. Recently, accordingly to their origin, two main subsets of Tregs have been described: thymus-derived Tregs (tTregs) and peripherally derived Tregs (pTregs). Numerous signaling pathways including the IL-2/STAT5 or the TGF-β/Smad3 pathways play a crucial role in segregating the two lineages....
متن کاملThymus-Derived, Peripherally Derived, and in vitro-Induced T Regulatory Cells
T regulatory cells (Tregs) are key players in immune regulation of both physiological and pathophysiological conditions. There are different Treg subsets but they can be divided into two major subsets: natural Tregs (nTregs) and adaptive/induced Tregs (iTregs); or as recently named, thymic-derived Tregs (tTregs) and peripheralinduced Tregs (pTregs), respectively. In addition, there are two subs...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1972
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.136.5.1323